scientific-computingresearch
bio-chipseq-differential-binding
Identifies differentially bound ChIP-seq regions between conditions using DiffBind (from BAMs), DESeq2, or PyDESeq2 (from count matrices). Handles normalization, statistical testing, and fold-change estimation with ChIP-seq-specific considerations. Use when comparing ChIP-seq binding between experimental conditions.
maintainer
GPTomics
Updated 3/28/2026
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quick start
Installation and usage
Identifies differentially bound ChIP-seq regions between conditions using DiffBind (from BAMs), DESeq2, or PyDESeq2 (from count matrices). Handles normalization, statistical testing, and fold-change estimation with ChIP-seq-specific considerations. Use when comparing ChIP-seq binding between experimental conditions.
Installation
$ install --globalskills.sh
Usage
Once installed, you can use this skill by running the following command in your terminal:
skills use bio-chipseq-differential-binding