bio-gene-regulatory-networks-perturbation-simulation
Simulate transcription factor perturbation effects on cell state using CellOracle, which integrates GRN inference with in silico knockout and overexpression modeling. Predicts cell identity shifts and differentiation trajectory changes from TF perturbations. Use when predicting the effect of transcription factor knockouts, planning perturbation experiments, or identifying driver TFs for cell fate transitions.
Installation and usage
Simulate transcription factor perturbation effects on cell state using CellOracle, which integrates GRN inference with in silico knockout and overexpression modeling. Predicts cell identity shifts and differentiation trajectory changes from TF perturbations. Use when predicting the effect of transcription factor knockouts, planning perturbation experiments, or identifying driver TFs for cell fate transitions.
Once installed, you can use this skill by running the following command in your terminal:
skills use bio-gene-regulatory-networks-perturbation-simulation