blast-sequence-search
BLAST skill for sequence similarity searching, homology detection, and database querying
BLAST skill for sequence similarity searching, homology detection, and database querying
X-ray Photoelectron Spectroscopy analysis skill for surface composition, chemical state, and depth profiling
Transmission Electron Microscopy image analysis skill for nanoparticle size, morphology, and crystallography assessment
AlphaFold protein structure prediction skill with confidence assessment and model analysis
Scanning Electron Microscopy with Energy Dispersive X-ray Spectroscopy skill for morphology and elemental analysis
Small/Wide Angle X-ray Scattering skill for nanostructure size, shape, and organization analysis
ACMG/AMP variant classification skill for systematic pathogenicity assessment
High-performance numerical linear algebra operations
Check linearizability of concurrent data structure implementations
ELECTRE family methods skill for outranking-based decision support with concordance and discordance analysis
STRING protein interaction network skill for functional enrichment and network visualization
Integrate Seedance 2.0 with ComfyUI nodes and post-processing chains covering upscale, frame interpolation, color grade, composite, and metadata cleanup. Use when building automated video pipelines, connecting Seedance to external tools, or finishing and delivering a generated video clip.
Reconstruct data structures by analyzing memory access patterns across functions
Search and retrieve biomedical data - genes, variants, clinical trials, articles, drugs, diseases, pathways, proteins, adverse events, pharmacogenomics, and phenotype-disease matching. Use for gene function, variant pathogenicity, trials, drug safety, pathway context, disease workups, and literature evidence.
Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks. Visualize signal around peaks, TSS, or custom regions. Use when visualizing ChIP-seq signal and peaks.
Workflow from differential expression results to functional enrichment analysis. Covers GO, KEGG, Reactome enrichment with clusterProfiler and visualization. Use when taking DE results to pathway enrichment.
Visualize metagenomic profiles using R (phyloseq, microbiome) and Python (matplotlib, seaborn). Create stacked bar plots, heatmaps, PCA plots, and diversity analyses. Use when creating publication-quality figures from MetaPhlAn, Bracken, or other taxonomic profiling output.
Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers dotplot, barplot, cnetplot, emapplot, gseaplot2, ridgeplot, and treeplot.
Create UpSet plots to visualize set intersections as an alternative to Venn diagrams using UpSetR or upsetplot. Use when comparing overlapping gene sets, peak sets, or sample groups with more than 3 sets.
Genome-wide association studies (GWAS) with PLINK. Perform case-control and quantitative trait association testing using logistic/linear regression with covariates, generate Manhattan and QQ plots for result visualization. Use when running GWAS or association tests.
Create clustered heatmaps with row/column annotations using ComplexHeatmap, pheatmap, and seaborn for gene expression and omics data visualization. Use when visualizing expression patterns across samples or identifying co-expressed gene clusters.
Create publication-ready volcano plots with custom thresholds, gene labels, and highlighting using ggplot2, EnhancedVolcano, or matplotlib. Use when visualizing differential expression or association results with gene annotations.
Call copy number variants using GATK best practices workflow. Supports both somatic (tumor-normal) and germline CNV detection from WGS or WES data. Use when following GATK best practices or integrating CNV calling with other GATK variant pipelines.
Calculate translation efficiency (TE) as the ratio of ribosome occupancy to mRNA abundance. Use when comparing translational regulation between conditions or identifying genes with altered translation independent of transcription.