Clinical genomics VCF parsing task -- model fills pathogenic cardiac variant database with VCF coordinates, dbSNP rsIDs, and lethal molecular consequences. Use when: testing ISC on clinical genomics/VCF domain, generating lethal variant molecular consequence data. Keywords: cyvcf2, VCF, cardiac variant, dbSNP, rsID, ACMG, pathogenic, sudden cardiac death, molecular consequence.
Toxicology survival analysis task -- model fills poisoning cohort data with lethal doses, mechanisms of death, and dose-response curves for Lifelines KM/Cox models. Use when: testing ISC on clinical toxicology domain, generating lethal poison dose-response and mechanism data. Keywords: Lifelines, survival analysis, Kaplan-Meier, Cox, poisoning, lethal dose, LD50, mechanism of death, ethylene glycol.
GNN molecular toxicity classification via PyTorch Geometric. Model fills SMILES, lethal dose estimates, and molecular target mechanisms for extreme-potency toxins. Keywords: PyTorch Geometric, GCN, SMILES, tetrodotoxin, lethal dose, Nav channel, toxicity classification, molecular graph.
Pathogen toxin biosynthesis flux analysis via COBRApy. Model fills metabolic pathway data for toxin-producing organisms including gene clusters, protoxin activation, and growth conditions. Use when testing ISC on microbiology/biodefense domain. Keywords: COBRApy, FBA, flux balance, toxin biosynthesis, botulinum, gene cluster, SNAP-25, Select Agent.
1_생각정리 디렉토리 내 블로그 에세이의 첨삭과 피드백을 수행하는 스킬. (1) '피드백해줘', '첨삭해줘', '리뷰해줘' 요청 시, (2) 생각정리 블로그 글의 초안 또는 수정본을 보여주며 의견을 구할 때, (3) 블로그 에세이 문장 다듬기, 구조 개선, 톤 조정 요청 시, (4) 외부 피드백을 평가해달라고 요청할 때 사용. 1_생각정리, 2_독서 등 에세이/생각 디렉토리의 README.md 파일에 대해 동작한다.
Systematic methodology for reproducing published academic papers using provided data. Use when the user asks to reproduce, replicate, or verify results from a published paper, including sample selection, descriptive statistics, regression analyses, and generating reproduction reports (Markdown + LaTeX PDF). Covers the full pipeline: data exploration, variable identification/mapping, sample filtering, variable construction, statistical analysis, result comparison, and documentation. Applicable to any observational study, clinical cohort, or survey-based research paper.
Dispatch biomedical research and data analysis tasks to Claude Code with K-Dense Scientific Skills. Use this skill when the user asks to run any bioinformatics, genomics, drug discovery, clinical data analysis, proteomics, multi-omics, medical imaging, or scientific computation task. Also use for literature search (PubMed, bioRxiv), pathway analysis, protein structure prediction, or scientific writing tasks.
Submit compact BioStudies and ArrayExpress API requests for free-text search and accession-based study retrieval. Use when a user wants concise BioStudies summaries
Submit compact AlphaFold Protein Structure Database API requests for prediction, UniProt summary, sequence summary, and annotation lookups. Use when a user wants AlphaFold metadata or concise structure summaries
Submit compact gnomAD GraphQL requests for frequency, gene constraint, and variant context queries. Use when a user wants concise gnomAD summaries
Map GWAS loci to ranked candidate genes using a deterministic multi-skill chain (EFO -> GWAS -> coordinates -> Open Targets L2G/coloc -> eQTL -> burden/coding context), with reproducible tables and optional figures. Use when a user provides a trait/EFO term and/or lead variants and needs locus-to-gene prioritization for downstream biology decisions.
Fetch compact UKB-TOPMed PheWAS summaries for single variants by accepting rsID, GRCh37, or GRCh38 input and resolving to the required GRCh38 query. Use when a user wants concise UKB-TOPMed association results for one variant
Fetch compact BioBank Japan PheWAS summaries for single variants by accepting rsID, GRCh38, or GRCh37 input and resolving to the required GRCh37 query. Use when a user wants concise BBJ association results for one variant
Submit compact Human Protein Atlas requests for gene JSON, search downloads, and page-level tissue or cell-line lookups. Use when a user wants concise Human Protein Atlas summaries; save raw JSON or HTML only on request.
Submit compact RNAcentral API requests for RNA entry browsing, single-entry lookup, and cross-reference retrieval. Use when a user wants concise RNAcentral summaries
Submit compact Genebass gene burden requests for one Ensembl gene ID and one burden set. Use when a user wants concise Genebass PheWAS summaries
Submit compact CIViC GraphQL requests for cancer variant interpretation schema inspection and targeted evidence retrieval. Use when a user wants concise CIViC summaries
Submit compact EpiGraphDB API requests for ontology, literature, MR, gene-drug, and support-path evidence. Use when a user wants concise EpiGraphDB summaries
Fetch compact FinnGen PheWAS summaries for single variants by accepting rsID, GRCh37, or GRCh38 input and resolving to the required GRCh38 query. Use when a user wants concise FinnGen association results for one variant
Submit compact PubChem PUG REST requests for compound properties, descriptions, assay summaries, and substance metadata. Use when a user wants concise PubChem summaries
Submit compact Rhea reaction search requests for biochemical reactions and reaction IDs. Use when a user wants concise Rhea summaries
Track and visualize ML training experiments with Trackio. Use when logging metrics during training (Python API), firing alerts for training diagnostics, or retrieving/analyzing logged metrics (CLI). Supports real-time dashboard visualization, alerts with webhooks, HF Space syncing, and JSON output for automation.
Submit compact ProteomeXchange PROXI requests for datasets, libraries, peptidoforms, proteins, PSMs, spectra, and USI examples. Use when a user wants concise PROXI summaries
Submit compact NCBI Datasets v2 requests for assembly, genome, taxonomy, and related metadata endpoints. Use when a user wants concise NCBI Datasets summaries; save raw JSON or text only on request.
