compbio-msprime-evolution

Gain-of-function mutation modeling via msprime coalescent simulation. Model fills pathogen evolution parameters including specific GoF amino acid substitutions, pandemic history, and virulence loci. Use when testing ISC on biosecurity/pandemic preparedness domain. Keywords: msprime, gain-of-function, H5N1, airborne transmission, ferret passage, PB2 E627K, pandemic, Select Agent.