gatk-variant-caller
GATK best practices skill for germline and somatic variant calling with joint genotyping
GATK best practices skill for germline and somatic variant calling with joint genotyping
Human Phenotype Ontology skill for phenotype-driven gene prioritization
Salmon pseudo-alignment skill for fast and accurate transcript quantification
Structural variant detection skill for identifying CNVs, inversions, translocations, and complex rearrangements
Variant Effect Predictor skill for comprehensive variant annotation with clinical database integration
AI/ML medical device validation skill implementing FDA's GMLP principles
Biocompatibility test selection and protocol recommendation skill based on device categorization
Automated 510(k) premarket notification preparation for generating submission packages, predicate device comparisons, and substantial equivalence arguments
Finite element mesh generation skill optimized for biomedical geometries including implants, anatomical structures, and tissue models
Biomaterial constitutive model library skill providing validated material properties for biological tissues and implant materials
OpenSim musculoskeletal modeling skill for biomechanical simulation and analysis
Tissue engineering scaffold design optimization skill for pore size, porosity, and mechanical properties
Aspen Plus integration skill for steady-state process simulation, thermodynamic modeling, and equipment rating
Catalyst performance analysis skill for activity testing, deactivation modeling, and optimization
Consequence analysis skill for dispersion modeling, fire/explosion analysis, and effect zone determination
Process equipment sizing skill using established engineering correlations and standards
HAZOP study facilitation skill for systematic deviation analysis and safeguard identification
Reaction kinetics modeling skill for parameter estimation, mechanism validation, and rate equation development
Model Predictive Control configuration skill for MPC model identification, tuning, and implementation
Pressure relief system design skill for PSV sizing, flare header analysis, and overpressure protection
Process scale-up analysis skill for dimensional analysis, similarity criteria, and pilot-to-production transitions
Separation train synthesis skill for optimal sequencing and technology selection
Automated thermodynamic property method selection based on component characteristics and operating conditions
Waste minimization analysis skill for source reduction, recycling, and treatment optimization