All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For structure validation, use boltz-2.
Query PubChem database for chemical structures, similar compounds, and bioactivity data. Use this skill when: (1) Converting drug name to molecular structure (SMILES, SDF), (2) Finding similar compounds for lead optimization, (3) Querying bioactivity data against protein targets, (4) Getting compounds active in specific assays.
Predict comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties for drug candidate molecules using GraphMVP ensemble models. Use this skill when: (1) Predicting blood-brain barrier penetration, (2) Assessing side effect profiles, (3) Estimating Caco-2 permeability, half-life, or LD50 toxicity, (4) Evaluating drug-likeness and safety of molecules.
Query ChEMBL database for bioactivity data on drug-like compounds. Use this skill when: (1) Finding compounds active against a protein target (target-based search), (2) Getting bioactivity profile for a molecule (molecule-based search), (3) Finding drugs for a disease indication (indication-based search).
Analyze protein mutations by retrieving protein data, explaining mutation effects, predicting protein structure, and visualizing results. Use this skill when the user asks about protein mutations, wants to understand mutation effects, or needs to analyze genetic variants. Triggers on phrases like "analyze mutation", "explain mutation", "what does this mutation do", "protein variant analysis".
Query UniProt database for protein sequences, metadata, and search by criteria. Use this skill when: (1) Looking up protein information by UniProt accession ID, (2) Searching proteins by gene name, organism, function, or disease, (3) Retrieving comprehensive protein metadata including domains, PTMs, and annotations.
Multi-phase iterative project analysis with Mermaid diagrams. Generates architecture reports, design reports, method analysis reports. Use when analyzing codebases, understanding project structure, reviewing architecture, exploring design patterns, or documenting system components. Triggers on "analyze project", "architecture report", "design analysis", "code structure", "system overview".
Generate software copyright design specification documents compliant with China Copyright Protection Center (CPCC) standards. Creates complete design documents with Mermaid diagrams based on source code analysis. Use for software copyright registration, generating design specification, creating CPCC-compliant documents, or documenting software for intellectual property protection. Triggers on "软件著作权", "设计说明书", "版权登记", "CPCC", "软著申请".
Transform vague prompts into actionable specs using intelligent analysis and session memory. Use when user input contains -e or --enhance flag.
Expert media production assistant. Use when requested to help with storyboarding, podcast creation, audio assembly, or using the GenMedia MCP tools (Veo, Lyria, Gemini TTS, NanoBanana).
Expert media production assistant. Use when requested to help with storyboarding, podcast creation, audio assembly, or complex multi-step media workflows using the GenMedia MCP servers (Veo, Lyria, Gemini TTS, NanoBanana).
Expert in audio synthesis, music generation, and mixing. Use when creating podcasts, background scores, or multi-track audio layering using mcp-chirp3-go, mcp-lyria-go, mcp-gemini-go, mcp-nanobanana-go, and mcp-avtool-go.
Expert in AI image generation and editing. Use when the user needs high-quality textures, character-consistent visuals, or image-to-image editing using mcp-nanobanana-go.
Expert in video composition, editing, and format conversion. Use when the user wants to generate high-quality video, overlay images on video, concatenate clips, create GIFs, or sync audio to video using mcp-avtool-go and mcp-veo-go.
Guide for designing and implementing command-line interfaces (CLIs) that are equally usable by human developers and automated coding agents. Use when the user wants to build a CLI, apply CLI best practices, or use Go with Cobra and Viper.
Extracts data from web pages using browser automation and CSS/JavaScript selectors. Use when you need to scrape titles/text/structured fields from live web pages or when the user mentions scraping, extraction, or selectors.
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).
Validates data against common and custom rules (required fields, formats, ranges). Use when checking data quality, input validation, or enforcing schemas and constraints.
A tiny test skill that runs a safe python script and echoes argv. Use to validate the skill script execution pipeline (allowed-tools gating, timeout, and output limits).
